Examples: Prilosec, Nexium, Prevacid
Used for: Acid reflux, GERD
What Research Suggests
Some studies have reported a possible association between long-term PPI use and dementia risk, although findings remain mixed and inconclusive.
Drugs& Medications
What to Do
Ask your doctor whether:
- A lower dose is appropriate
- Shorter treatment duration may help
- Alternatives such as H2 blockers (for example, famotidine) are suitable
6. Overactive Bladder Medications
Examples
- Oxybutynin (highest concern)
- Tolterodine
- Solifenacin
What to Do
Discuss possible alternatives, including:
- Mirabegron
- Pelvic floor therapy
- Bladder training exercises
7. First-Generation Antihistamines
Examples
- Diphenhydramine (Benadryl)
- Chlorpheniramine
- Hydroxyzine
- Doxylamine
What Research Suggests
Long-term use has been associated with cognitive decline because these medications can affect brain signaling pathways.
LanguageResources
What to Do
Ask about newer antihistamines that may have lower cognitive risk, such as:
- Cetirizine
- Loratadine
- Fexofenadine
8. Statins (Controversial)
Used for: High cholesterol