- A 15% increased risk of dementia
- A 21% increased risk of Alzheimer’s disease
The association appeared stronger with long-term use.
What to Do
Short-term use is generally considered lower risk. If you use these medications long term, ask your doctor about tapering strategies or alternatives such as cognitive behavioral therapy (CBT).
2. Anticholinergic Drugs (High Concern)
Used for: Overactive bladder, allergies, depression, Parkinson’s disease, COPD
HealthConditions
What Research Suggests
Studies suggest the risk may increase with longer use:
- 1–89 days: approximately 10% higher risk
- 1–3 years: approximately 49% higher risk
- More than 3 years: approximately 66% higher risk
Common Examples
- Oxybutynin
- Diphenhydramine (Benadryl)
- Amitriptyline
- Nortriptyline
- Hydroxyzine
- Cyclobenzaprine
What to Do
Request a medication review with your healthcare provider. In many cases, safer alternatives may be available.
Drugs& Medications
Used for: Insomnia
What Research Suggests
Frequent use of certain sleep aids has been associated with a higher risk of dementia in some studies.